Marstons Mills (also spelled Marston's Mills) is a village in the town of Barnstable, Massachusetts, United States. It was settled by Roger Goodspeed before 1653. His granddaughter Lydia married Benjamin Marston who developed the fulling mill and weaving operations along the Marstons Mills River, hence the name of the village. It is primarily residential, located on Massachusetts Route 28, and rural in nature. Main roads also include Massachusetts Route 149, Race Lane, River Road, Osterville-West Barnstable Road, and Santuit-Newtown Road. The ZIP code for Marstons Mills is 02648.