East Palestine (/ˌpæləˈstiːn/ PAL-ə-STEEN) is a village in eastern Columbiana County, Ohio, United States. The population was 4,721 at the 2010 census. Located on the Ohio-Pennsylvania border, East Palestine is 20 miles south of Youngstown and 50 miles northwest of downtown Pittsburgh. East Palestine is located in the Salem, OH Micropolitan Statistical Area, as well as the southern regions of the greater Mahoning Valley.
East Palestine is located along the Norfolk Southern Railway, and has a freight train station.