Wappapello is an unincorporated community in southeastern Wayne County, Missouri, United States. It is located about thirteen miles northeast of Poplar Bluff next to Lake Wappapello.
Wappapello was laid out in 1884 when the railroad was extended to that point. The community has the name of a Native American chieftain. A post office called Wappapello has been in operation since 1884.