South Fork is an unincorporated community and census-designated place (CDP) in Howell County, Missouri, United States. It is located 10 miles (16 km) southwest of West Plains on U.S. Route 160. As of the 2010 census it had a population of 241.
A post office called South Fork was established in 1860, and remained in operation until 1960. The community was named after the nearby South Fork of the Spring River.