Sauk Centre is a city in Stearns County, Minnesota, United States. The population was 4,317 at the 2010 census. It is the birthplace of Sinclair Lewis, a novelist and winner of the Nobel Prize in Literature, and Sauk Centre served as the inspiration for Gopher Prairie, the fictional setting of Lewis's 1920 novel Main Street.
Sauk Centre is part of the St. Cloud Metropolitan Statistical Area.