Rushville is a city in Rushville Township, Rush County, in the U.S. state of Indiana. The population was 6,341 at the 2010 census. The city is the county seat of Rush County. It was the campaign headquarters for Wendell Willkie's 1940 presidential campaign against Franklin D. Roosevelt. Willkie is buried in the city's East Hill Cemetery. It, like the county, was named in honor of Dr. Benjamin Rush, who signed the Declaration of Independence.