New Salisbury is an unincorporated census-designated place (CDP) in Jackson Township, Harrison County, Indiana, United States. As of the 2010 census it had a population of 613. The community is centered on the intersection of State Highway 135 and State Highway 64, about 7 miles (11 km) away from Corydon, the county seat.
Businesses in New Salisbury include two gas stations, two grocery stores, a drug store, a bank, a veterinarian's office, doctor offices, a transport company, and a manufacturing company. The area is within the North Harrison Community School Corporation.
The area has submitted to the state of Indiana to be incorporated. If approved, New Salisbury would be the fourth largest town in Harrison County. Currently the area is governed by the Harrison County government and represented by a council member on the County Council.