Guthrie is a small town in, and the county seat of, King County in the U.S. state of Texas. It lies at the junction of U.S. Routes 82 and 83, ninety-six miles east of Lubbock. It serves as the principal headquarters of the Four Sixes Ranch. and is the only community within its namesake Census Designated Place (CDP). As of the 2010 Census the population was 160.