Friendship is a census-designated place in western Nile Township, Scioto County, Ohio, United States. As of the 2010 census it had a population of 351. Although it is unincorporated, it has a post office, with the ZIP code of 45630. It lies along U.S. Route 52.
The citizens of Friendship are served by the Nile Township Volunteer Fire Department and the Washington-Nile Local School District (Portsmouth West High School).