Saltillo is an unincorporated community in Hopkins County, Texas, in the United States.
It is located sixteen miles east of Sulphur Springs at the intersection of US 67 and FM 900. Saltillo has a population of approximately 200. Despite being unincorporated, Saltillo does have its own post office, assigned the ZIP code of 75478.
The Saltillo Independent School District serves area students.
On January 13, 1985, Saltillo was the location of a car chase and shootout between FBI agents, Texas Rangers, and a group of kidnappers. Two of the six kidnappers were wounded in the gunfight, and their hostage, a thirteen year old girl, was rescued unharmed. The case was later featured in an episode of The FBI Files.
The church of Christ, at the intersection of US Highway 67 and Farm to Market Road 900, has served the community for may years. Recent pulpit ministers include Wendell Hutchins and Mike Long.