St. Libory is an unincorporated community and census-designated place (CDP) in southeastern Howard County, Nebraska, United States. As of the 2010 census it had a population of 264.
It lies along U.S. Route 281, 11 miles (18 km) southeast of the city of St. Paul, the county seat of Howard County. Its elevation is 1,863 feet (568 m) above sea level. Although St. Libory is unincorporated, it has a post office, with the ZIP code of 68872. St. Libory is known in the region for its fresh melon market.