Piedmont is a city in Calhoun and Cherokee counties in the U.S. state of Alabama. The population was 4,878 at the 2010 census. It is included in the Anniston-Oxford, Alabama Metropolitan Statistical Area. Many surrounding communities are served by the 36272 ZIP code, including Spring Garden, Rock Run, Knighten's Crossroads, and Nance's Creek. The current mayor is Bill Baker, who was chosen by the city council to lead after elected mayor Rick Freeman resigned due to medical issues.