Picacho[needs IPA] is an unincorporated community and census-designated place in Pinal County, Arizona, United States. The population was 471 at the 2010 census.
Picacho is located near Interstate 10 4.5 miles (7.2 km) southeast of Eloy and 7 miles (11 km) northwest of Picacho Peak State Park. Picacho has a post office with ZIP code 85241, which opened in 1881. The community's name is Spanish for "peak" and is derived from the Picacho Mountains. Picacho has a ZIP Code of 85241; in 2000, the population of the 85241 ZCTA was 521.
By late 2012 parts of Picacho will be removed under Arizona eminent domain law on account of Interstate 10 expansion.