Ono is an unincorporated community in East Hanover Township, Lebanon County, Pennsylvania, United States, on U.S. Route 22 and about two miles SW of the junction of Interstate 78 and Interstate 81. The Swatara Creek to the south drains it into the Susquehanna River. While Ono has its own post office with the zip code of 17077, some residents are served by the Annville or Jonestown post office, with the zip code of 17003 or 17038, respectively.
According to tradition, the name Ono was selected after all other ideas were rejected by a town elder with "O! No."