Mooresville is a town in Limestone County, Alabama, United States, located southeast of the intersection of Interstate 565 and Interstate 65, and north of Wheeler Lake.
The town is between Huntsville and Decatur, and is part of the Huntsville-Decatur Combined Statistical Area; its population as of the 2010 census is 53, down from 59 in 2000.
Although the town's per-capita income is over $50,000, Mooresville is within the area covered by the charter for the Appalachian Regional Commission, an organization whose goal is to help increase the per-capita income of impoverished areas. Mooresville is within Corridor V of the Appalachian Development Highway System.
The town was the primary filming location for Disney's Tom and Huck (1995).