Lukeville is a small populated place on the U.S.-Mexico border in southern Pima County, Arizona, United States.
The community consists of the Lukeville Port of Entry border crossing into Sonoyta, Sonora, Mexico, together with a gas station, a US Post Office, a duty-free shop, and a stop-over spot for buses that are bound for Phoenix and Tucson. It is the terminus of State Route 85 and is located entirely within Organ Pipe Cactus National Monument.
Its population was approximately 35 at the 2000 census, 27 (77%) of whom were Hispanic or Latino.
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