Damascus is a census-designated place (CDP) in southwestern Goshen Township in Mahoning County and northwestern Butler Township in Columbiana County in the U.S. state of Ohio. As of the 2010 census, it had a population of 443. Damascus has a post office, with the ZIP code of 44619. The Mahoning County portion of Damascus is part of the Youngstown-Warren-Boardman, OH-PA Metropolitan Statistical Area, while the Columbiana County portion is part of the Salem, OH Micropolitan Statistical Area.
The community lies at the intersection of U.S. Route 62 and State Routes 173 and 534.