Clewiston is a city in Hendry County, Florida, United States. Its location is on the Atlantic coastal plain. The population was 7,155 at the 2010 census, up from 6,460 at the 2000 census. The estimated population in 2015 was 7,505. The city is located on the south bank of Lake Okeechobee, and the Lake Okeechobee Scenic Trail passes through the edge of the city. The city is home to the Clewiston Museum and the Dixie Crystal Theatre. The area has been home to Seminole tribe members and sugar plantations. The Ah-Tah-Thi-Ki Seminole Indian Museum is located 32 miles south of the city.