Catawissa is a small unincorporated community in Franklin County, Missouri, United States, on the St. Louis & San Francisco Railroad, 39 miles from St. Louis and four miles south-southeast of Pacific. It is located at the junction of Route N and Route O, southwest of Pacific. Winch Creek flows past the eastern margin of the community.
Catawissa was laid out in 1858, and most likely was named after Catawissa, Pennsylvania. A post office called Catawissa has been in operation since 1860.
The population 2,201 (2000 Census for Zip Code 63015 - Catawissa).