Toksook Bay (TOOK- sook or TUCK-sook) (Nunakauyaq, Tuksuk in Central Alaskan Yup'ik) is a city and village on Nelson Island in Bethel Census Area, Alaska. The population was 590 at the 2010 census, up from 532 in 2000. As of 2016, the estimated population was 657, making it the largest village on the island.
Toksook Bay was established in 1964 by residents of nearby Nightmute. Almost the entire population are members of the Alaska Native Nunakauyarmiut ('People of Nunakauyaq'), who rely on fishing and other subsistence activities.