Smiths Station is a city in Lee County, Alabama, United States. It is part of the Columbus, Georgia-Phenix City, Alabama Metropolitan Statistical Area. At the time of the 2000 census, it was still a census-designated place (CDP), and its population was 21,756. The area that incorporated as Smiths Station in 2001 was much smaller than the CDP, and contained a population of 4,926 by the 2010 census. Smiths Station, known to locals as "Smiths", is a bedroom community of Columbus, Georgia and Phenix City, Alabama. Smiths Station High School has an enrollment of over 1,800 students and is the 11th largest high school in the state.