Pierce City, formerly Peirce City, is a city in Lawrence and Barry counties, in southwest Missouri. The population was 1,292 at the 2010 census. In 2010, the town annexed property along Route 97 into Barry County to a point just north of U.S. Route 60.
It is notable for its white residents having driven out virtually all of its 300 black residents in 1901, after a lynch mob killed three black men who were suspects in a murder of a white woman. Whites took over the land and property left by the blacks, and the events were treated as secret for decades. The city has remained overwhelmingly white in population.