Montrose is the Home Rule Municipality that is the county seat and the most populous municipality of Montrose County, Colorado, United States. The city population was 19,132 at the 2010 United States Census. The main road that leads in and out of Montrose is U.S. Highway 50. The town is located in cardinal-western Colorado, in the upper Uncompahgre Valley and is an economic, labor, and transportation waypoint for the surrounding recreation industry. Demographically, the town is majority white, with a large Hispanic population. It is also the home of a few major engineering projects, namely the Gunnison Tunnel.