Leslie is a city in Searcy County, Arkansas, United States. Located within the Boston Mountains, the most rugged subset of The Ozarks, the city was founded as a railroad and lumber town. Renamed from the original Wiley's Cove in 1887, the city saw prosperity relating to these industries through the 1920s. Today, this history is available to residents and visitors in the form of several properties listed on the National Register of Historic Places throughout the city. The population was 441 at the 2010 census.