Isle La Motte is an island in Lake Champlain in northwestern Vermont, United States. It is the most remote and northern of the Champlain Islands. It is 7 by 2 miles (11.3 by 3.2 km). It lies close to where the lake empties into the Richelieu River. It is incorporated as a New England town in Grand Isle County. The population was 471 at the 2010 census.
The island is named after French soldier Pierre La Motte who built a military outpost on the island in 1666. The island population swells many times over in the summer months. The island is the site of Fort Sainte Anne, Saint Anne's Shrine, the Methodist Episcopal Church of Isle La Motte, the Fisk Quarry and Goodsell Ridge Preserves, the Isle La Motte Elementary School, and the Isle La Motte Lighthouse.