Florence is a city in, and the county seat of, Lauderdale County, Alabama, United States, in the state's northwest corner.
According to the 2010 census, the city's population was 39,319.
Florence is the largest and principal city of the Florence-Muscle Shoals Metropolitan Statistical Area (which includes Muscle Shoals, Sheffield, and Tuscumbia metropolitan areas in Colbert and Lauderdale counties). Florence is considered northwestern Alabama's primary economic hub.
Annual tourism events include the W. C. Handy Music Festival in the summer and the Renaissance Faire in the fall. Landmarks in Florence include the Rosenbaum House, the only Frank Lloyd Wright-designed home located in Alabama.
Florence and Lauderdale County have one hospital, Eliza Coffee Memorial Hospital. ECM is a 358 bed facility owned by RCCH HealthCare Partners in Brentwood, Tennessee. In 2010 RCCH HealthCare Partners announced that they would build a new hospital in Florence. The hospital is due to be completed in December 2018.
The type of municipal government is mayor-council.