Des Arc is a city on the White River in the Arkansas Delta, United States. It is the largest city in Prairie County, Arkansas, and the county seat for the county's northern district. Incorporated in 1854, Des Arc's position on the river has shaped its culture, history, and economy, beginning as a major lumber shipping port but leaving the city vulnerable to major floods in 1927 and 1937. As river shipping declined, Des Arc was bypassed by railroads, Interstate highways, and much of the post-industrial society. Des Arc's history is preserved by seven listings on the National Register of Historic Places, and the region's history is interpreted at Lower White River State Park. The city's population stopped growing in the 1980s and has been declining since, with a population of 1,717 at the 2010 Census.