Clayton is a village in Lenawee County of the U.S. state of Michigan. The population was 344 at the 2010 census. The village is situated on the boundary between Hudson Township on the west and Dover Township on the east, with a portion of the village in each.
M-34 (or W. Carleton Rd.) passes along the south side of the village, while M-156 has its northern terminus at the junction with M-34. The road, also known as Morey Highway, continues north through the village.