Isabella is a small, unincorporated community in Ozark County, Missouri. It is located about thirteen miles west of Gainesville and two miles east of Theodosia and Bull Shoals Lake along U.S. Highway 160. Although it is unincorporated, Isabella has a post office with the ZIP code 65676.
A post office called Isabella has been in operation since 1856. An early postmaster gave the community the name of his daughter, Isabella Brattin.