Winston-Salem State University (WSSU), a constituent institution of the University of North Carolina, is a historically black public research university located in Winston-Salem, North Carolina, United States. It is a member-school of the Thurgood Marshall College Fund.

Winston-Salem State has been ranked #27 by U.S. News & World Report in the Top Public Comprehensive Baccalaureate Colleges of the South category for the last nine years (2001–2009). WSSU is a recognized regional institution offering baccalaureate and graduate programs to a diverse student population.

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