The University of Puerto Rico, Río Piedras (Spanish: Universidad de Puerto Rico, Recinto de Río Piedras), also referred to as UPR-RP, is a public research university located on a 289-acre (1.17 km2) campus in Río Piedras, San Juan, Puerto Rico.

UPR-RP serves more than 18,000 students, 20% graduate, and grants an average of over 3,000 degrees a year. It is recognized by the Carnegie Foundation for the Advancement of Teaching as an Intensive Doctoral/Research University. As a public comprehensive doctoral institution, its academic offerings range from the baccalaureate to the doctoral degree, through 70 undergraduate programs and 19 graduate degrees with 71 specializations in the basic disciplines and professional fields. UPR‐RP has consistently granted the largest number of doctorate degrees to Hispanics in the US.

UPR-RP is the largest campus in terms of student population of the University of Puerto Rico System, and is the first public university in the history of Puerto Rico.

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