South Plains College is a junior college located in Levelland, Texas. It operates satellite branches in Plainview and at the Reese Technology Center, formerly Reese Air Force Base, in Lubbock. SPC also has many classes in the Byron Martin Advanced Technology Center in Lubbock, as part of a joint venture with the Lubbock Independent School District. SPC also has distance education centers located in Muleshoe, Littlefield, and Denver City.

In addition to their distance education programs, the school also provides Internet courses to its students as well as dual credit courses to high schools in the West Texas area.

In 1989, the college honored the Mayfield Brothers, Smokey Mayfield (1924–2008) and Herbert Mayfield (1920–2008), for their contributions to Bluegrass music in West Texas. A third Mayfield, Thomas Edd Mayfield (1926–1958) died of leukemia while on tour with Bill Monroe.

As defined by the Texas Legislature, the official service area of South Plains College is the following:

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