Wytheville (/ˈwɪθvɪl/) is a town in, and the county seat of, Wythe County, in western Virginia, United States. It is named after George Wythe, a signer of the United States Declaration of Independence, and mentor to Thomas Jefferson. Wytheville's population was 8,211 at the 2010 census. Interstate Highways 77 and 81 were constructed to intersect at the town, long a crossroads for travelers.
During the American Civil War, Wytheville had a strategic importance. It was attacked in 1863 (Toland's Raid) and 1865 (Stoneman's 1865 Raid). The town is the birthplace of Edith Bolling Wilson, second wife of President Woodrow Wilson.
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