Wayne is a village in DuPage and Kane counties, Illinois, United States. The eastern portion, in DuPage County, is in Wayne Township, while the western portion, in Kane County, is in St. Charles Township. The population was 2,431 at the 2010 census. and 2,490 as a 2012-2016 five year population estimate with over 70% of families reporting income over $100,000 in census figures.
In the late 19th and early 20th century, Wayne was a prominent center of horse breeding and farming research. The community was known for breeding French Percheron horses, a draught horse similar to a Clydesdale.