Oro Grande is an unincorporated community in the Mojave Desert of San Bernardino County, California, United States. It lies on the city boundary of Victorville and Adelanto. It is at 3,000 feet (910 m) elevation in Victor Valley north of the San Bernardino mountain range. It is located on old Route 66 near Interstate 15 between Victorville and Barstow. The ZIP code is 92368 and the community is inside area codes 442 and 760. Less than 1,000 residents live in the unincorporated area.
Neighboring townships include Silver Lakes, Helendale, Adelanto and Victorville.