Muscoda is a village in Grant and Iowa counties in the U.S. state of Wisconsin. The population was 1,299 at the 2010 census. Of this, 1,249 were in Grant County and 50 were in Iowa County. The Grant County part of the village is adjacent to the Town of Muscoda and the Iowa County part is adjacent to the Town of Pulaski. Muscoda is the largest village in Grant County.