Metlakatla /ˌmɛtləˈkætlə/ (Tsimshian: Maaxłakxaała "Saltwater pass") is a census-designated place (CDP) on Annette Island in Prince of Wales-Hyder Census Area, Alaska, United States. At the 2000 census the population was 1,375; this had grown to 1,405 by the 2010 census.
Since the late 19th century, it has been the major settlement of the Metlakatla Indian Community of the federally recognized Annette Islands Reserve, the only reserve in Alaska and U.S. The Metlakatla voted to opt out of the Alaska Native Claims Settlement Act of the 1970s and retained rights to their land and waters. Membership in the community is primarily by lineage; it consists primarily of Tsimshian people and also includes those from other Alaskan Native tribes who wish to join the Metlakatla Indian Community as a bona fide member. Bona fide membership is granted upon approval of the Metlakatla Tribal Council and Executives.