Liberty Center is an unincorporated community in southern Warren County, Iowa, United States. It lies along U.S. Route 65 south of the city of Indianola, the county seat of Warren County. Its elevation is 1,024 feet (312 m), and it is located at about 41°12′16″N 93°30′0″W / 41.20444°N 93.50000°W / 41.20444; -93.50000 (41.2043016, -93.4999210). Although Liberty Center is unincorporated, it has a post office, with the ZIP code of 50145, which opened on 7 March 1865.
Liberty Center was laid out in 1875.