Lepanto is a city in Poinsett County, Arkansas, United States. The population was 1,893 at the 2010 census. It is included in the Jonesboro, Arkansas Metropolitan Statistical Area. Lepanto was named for the Greek seaport of Lepanto, site of a great crusade sea battle in 1571. Lepanto was a site for the filming of the TV movie version of John Grisham's book A Painted House.