Ermine is an unincorporated community in Letcher County, Kentucky, United States. Its ZIP Code is 41815.
A post office was established in the community in 1904. The origins of the place name Ermine are unclear: it might have named for the first postmaster Ermine Webb, resident Ermine Hall, or resident Ermine Craft. Letcher County Central High School was established in the area in 2005.