Dyess is a town in Mississippi County, Arkansas, United States. The town was founded as Dyess Colony in 1934 as part of the Roosevelt administration's agricultural relief and rehabilitation program and was the largest agrarian community established by the federal government during the Great Depression. The town is best remembered as the boyhood home of country singer-songwriter Johnny Cash. The surviving original buildings of the colony period and Johnny Cash's boyhood home are listed on the National Register of Historic Places as the "Dyess Colony Center" and "Farm No. 266, Johnny Cash Boyhood Home."