Defiance is an unincorporated community and census-designated place in Broad Top Township, Bedford County, Pennsylvania, in the United States. The village was home to 239 residents, as of the 2010 census. It is located along Six Mile Run Road (State Route 1036).
There are five major employers in Defiance: Broad Top Township, local government and road maintenance, Tri County Petroleum, the Defiance Station Store and Deli, and the Defiance Elementary School branch of Tussey Mountain School District.
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