Daniel is a census-designated place in Sublette County, Wyoming, United States. The population was 150 at the 2010 census.
The town lies on US Route 189, in the Green River valley as the water flows out of the Gros Ventre Range to Daniel's north and the Wind River Mountains to the town's east. Horse Creek, a Green River tributary that joins just west of Daniel, has its headwaters west in the Salt River Range. Thus bordered on three sides by nearby mountains, Daniel lies in the very northern, highest part of the large basin that defines much of southern Wyoming. Wyoming Highway 354 is a west-east road that intersects US Highways 189 and 191 north of town.