Clarence is a village in Natchitoches Parish, Louisiana, United States. The population was 499 at the 2010 census. It is located some seven miles east of the parish seat of Natchitoches and is part of the Natchitoches Micropolitan Statistical Area.
Still owned by descendants of its founders, Grayson Barbeque, with a smokehouse, is the best known business in Clarence. It is located on U.S. Highway 71 near the intersection with U.S. Highway 84, which leads to Winnfield.