Blissfield is a village in Lenawee County in the U.S. state of Michigan. The population was 3,340 at the 2010 census. The village is located within Blissfield Township. The Blissfield post office first opened March 28, 1828. Hervey Bliss, who was the first white settler in 1824 and for whom the town is named, was the first postmaster.